On finding an unresponsive 30-year-old male next to an empty bottle of Valium, what should you do first?

In this scenario, the priority action is to open the airway of the unresponsive individual. When someone is unresponsive, there is a risk of airway compromise due to the inability to maintain patency on their own. By opening the airway, you ensure that any potential obstruction is cleared, allowing for adequate ventilation and oxygenation, which are critical for the patient's survival.

Considering the context of a potential overdose from a depressant like Valium, managing the airway becomes even more vital, as respiratory depression is a common concern. Once the airway is opened, you would then proceed to assess vital signs and consider further medical interventions, such as administering naloxone if indicated. Opening the airway forms the crucial first step in the resuscitation process to stabilize the patient's condition.