In the context of allergic reactions, what is the role of mast cells?

Mast cells play a crucial role in the body’s immune response, particularly in the context of allergic reactions. When an allergen is encountered, mast cells are activated and release various chemicals, with histamine being one of the primary substances. Histamine contributes to the symptoms commonly associated with allergic reactions, such as swelling, redness, and itching, by causing blood vessels to dilate and become more permeable.

In the process of an allergic response, the release of histamine is significant because it leads to the physiological changes that characterize an allergy, such as increased mucus production and bronchoconstriction in asthma. Thus, the correct recognition of the role of mast cells in releasing histamine is key in understanding how allergic reactions operate and how treatments like antihistamines function to alleviate symptoms.